The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well end in a rise in methadone plasma concentrations, which could result in possibly lethal respiratory melancholy. Also, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2